Still using ISBoxer and gotta say, just got my main team to 90, and now working on my Pally DK team. Now i'm not one for PVP so i'm not going to run them till I feel comfortable, however doing bloodfurnace right now and sure a couple wipes but thats due to macro imperfection, and or gear. I setup Death Grip on a Round-Robbin, and Death and Decay on a "Next Click". Did it in seconds, and got it working with ease. Gotta say that in the Year and 7 Months I've been using ISBoxer, I continue to be impressed. I still had Pwnboxer active when I switched over, and I found that after using ISBoxer, I had come to be accustomed to the advanced features, that Pwnboxer just couldn't cut it for me. I even had the update before my account went inactive, and I think some of the changes allowed for a form of click regions similar to ISBoxer, but nowhere close to the accuracy and efficiency of the VideoFX feature with repeater passthrough.

My official Rating
Pwnboxer 3/5 Stars
Due to its ease of use for simple boxability, mouse repeater lacks in accuracy and experienced bugs in it.

ISBoxer, 5/5 Stars
Due to its advanced features, fast window switcher, video FX feature, perfect mouse repeater, ability to turn on and off mapped keys and global repeater within wow without the need to tab out (or mouse over to another monitor). And the ability to get a free trial.

Overall:
Both cost around 50$, one offers 10x the functionality. You do the math. Would you prefer a Brick Cell Phone or a smart phone with internet abilities, texting, tweeting, 3D Gaming, need I go on?