Yes. You don't multibox by "driving" both characters at once (with a very few specific exceptions and for very short periods of time). You follow your main by using /follow macros.
For Rift (assuming your main char is named Beelzebubble):
/targetexact beelzebubble
/follow
/targetlasttarget
There are tweaks to that macro based on how you use targeting and focus but that's the basic idea.
[edit] Note that you will want to prevent normal movement keys from getting to your alt until/unless he is your actively-controlled character. I'll let others describe that in terms of ISBoxer setup.
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