Lax basically said, have a clean profile with nothing in it, start it and end process while IS Boxer was running.
He said I'd have to do that once, and if I unplugged/replugged the keyboard I'd have to do it again.

In my personal experience, I need to start and end-process every time I start Inner Space, if I want it to not have the default G1 = F1 type of behavior.
I have the Profiler software and Inner Space on the Quick Launch bar, and end-process which takes an extra 10-15 seconds each time I boot up the computer with the intention of boxing.

I've never tried a profile on the G15, after getting IS Boxer.
The G15 was purchased for boxing, Keyclone at the time.

Sildenafil's response makes sense.
If you run the Profiler as an Administrator you can use its software in conjunction with IS boxer.
If you end-process, then IS Boxer knows those keys are available and not used.