The G-Keys have two options for use.

You can run the Profiler software as an Administrator.
In which case, you would assign a key combination to each G-Key.
So when you push G1, it might send Alt + Shift + A... and G2 might be Alt + Shift + B, or whatever.
And then you have macros on those keybinds.

If you clear our the software so it is a totally blank profile.
No repeater options, no toggle options, nothing set at all.
You can start Profiler, while Inner Space is running and then end process.
At which point you can use the G-Keys as hotkeys for a mapped key.
If you go this route, you can also use M1, M2, M3 and the MR buttons as toggles and tie light on and light off to these buttons, as a visual confirmation on the mode you are in.
Also G1 is then an option for modifier keys with Shift G1, Alt G1, Ctrl G1 all being different than plain G1.
You need to select G-Keys from the drop down menu, rather than just pushing them as hotkeys.