Below is linked a rather boring video of me using ISBoxer mouse repeater and video feeds to interact with quest givers in RIFT. This is the best way I have found to work around the lack of IWT in RIFT. I use the same method for looting on my slaves.

http://www.youtube.com/watch?v=lBxMm9fnXvw - best watched in full screen 1080p so you can see the slave mouse cursors in the feeds.

Video recorded using local recording with XSplit. http://www.xsplit.com/
The 5 full screen video feeds down the left side are on my second monitor.