I use a G15, there is a mod at curse-gaming.com for the G15 keyboard that lays the buttons out on your screen like they are on you keyboard, really useful...

As far as macros, it is possible to fully automate your character using the macros outside of the game, it's not legal at all as it is a form of botting, but i wanted to see if it was possible so i set one up and i would press one button and it would kill a npc no problem, but i just tried it once and deleted it cause i do like playing the game and dont want to get banned. :P