hi Taipan,
  1. no real recommended cpu settings. personally, i'd let the OS figure it out... but i could be wrong. i don't have a quad. personally, i could easily imagine multiple hard drives to improve performance
  2. i believe keyclone's cpu affinity was implemented before wow had any such capability. if your goal would be to assign each wow to a different core (assuming 4 wows).. then you would need multiple wow directories with a different config.wtf in each (in order to keep the cpu affinity mask settings correct between clients). in that case, setting keyclone to 'NONE' would insure it wouldn't interfere with wow's cpu setting