assuming you have 5 wows on the machine, and you want 1 wow full screen and a 2x2 on the other... i believe this would work:

1680 x 1050 x 2 would mean a region that is 3360 x 1050

region0: 0,0 1680,1050
region1: 1680,0 840,525
region2: 2520,0 840,525
region3: 1680,525 840,525
region4: 2520,525 840,525