To me anything short of tiling on the same screen causes you to rely on peripheral and rubber necking too much. With that said I use a two monitor setup now, with the primary being my tank only with my 4 dps'ers on the second monitor. With Jamba, and a custom UI I rarely have to worry about the other screens. I want to upgrade my primary computer to handle 5 boxing. I think 1 large window with 4 tiled on the side is the best way to go. I just wish PiP was a bit faster.

Sam.. for love of pete please... clean up your desktop I have not seen that many icons randomly tossed up on a single screen let alone multiple. :)