I've only done some basic work with using keycasting with ISBoxer but I think that a more reliable method will be to setup your Overview so it doesn't show your own ships (a PVP tab is best bet for this)
Then you can use the keyboard to switch to over view, scroll up to nearest target, then press a key to lock them. I'm using the arrow keys for overview selction/scrolling adn then T to lock.
But I haven't done more than a little PVE with this setup and only 3 ships. It works much better with identical ships in PVE.
The mouse broadcasting seemed a bit unreliable in comparison.
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