So if I have my DK Setup:

Spam Button 1 - Down
Assist
IWT
Howling Blast - Keybind F10

Spam Button 1 - Up
HB - F10
HB - Shift + F10
HB - Ctrl + F10
FS - Alt + F10
FS - Alt + Ctrl + F10
NS - Ctrl + Shift + Alt + F10
BS - Ctrl + Shift + F10

I could change them to do the macro in Game Helpers as:

/cast Howling Blast - Keybind F10
/cast Spell - Keybind Shift + F10

Is that how I would do it?