Your most basic decision is a software to box with.

After that is your assist approach.
If you can do FTL (or your software does that), go with FTL.
If not, go with a Focus assist, as that is the next most flexible.

The guide Khatovar linked, covers all this.

If you haven't started yet, be sure to check out the Recruit a Friend (RAF) promotion.
That rocks.