I'm not sure whether you're in blood or unholy presence, I stay in blood for the whole instance. Kill the officer first, built in mind freeze is enough for interrupts. The only thing that you need to watch out for is the disease that he drops on the ground, move out of it fast. If the adds get a cast in it's not a massive problem but does make healing a little more bursty, the breath is not a problem, move out of it if you can, if not then it doesn't really matter.
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