I used to play with a N52 (original version). The main difference was when I started moving characters with the D-pad. So many available keys under my "productive" fingers. It takes a bit of time to get used to, but it is well worth it/

I moved to a Logitech G13 since then, I think it is superior to the N52 in every possible way. I am of course using the thumb-stick to move characters around.