Minor update on this topic:

Last night i upped the bar a little and graduated to quad boxing all on one machine w/ a "goldeneye 4-player" screen setup. Just out of curiosity i decided to not specify processor affinity on anyof the windows and to my surprise i was getting significant boosts to FPS on all 4 screens (only 1 of the three "background" screens was capped at 15fps, rest were crusing at 30+) with my main's screen capped at 60 from Vsync. All graphics are maxed with the exceptionof the resolution of course. The only down side is that load/draw times seem to be a little longer in some areas, but once they are rendered the game is smooth.

My setup:

Core2Duo 2.6ghz

2g DDR

EVGA GeForce 8800GTX