Shania, I had a similar issue.

As Lax pointed out.
1. ensure ISBoxer checkbox is enabled in the addon, for each toon logged in.
2. ensure your wow keybinds are set to default ( you can change them back later ).
3. If you are using Jamba too, ensure that the group names are set up correctly with Jamba.
4. (I know this sounds stupid), be sure you are runing the current version.

The only other thing there that I messed up once before, ensure the character names are correctly set up in ISBoxer. I goofed a Ô once and got a different character.

Another suggestion, you stated you have already deleted your old profile, and made a new one. I had to do this once I got the names wrong. Well, I didnt "have to" but its what I did, and it worked fine.

At the top of the screen, click on the Wizard, and just follow the instructions. When asked to set up the follow, assist, target, etc at the end, ... read them carefully.