I use only two macros for IsBoxer. One for assist and one for auto-follow. That is like 0.001% of the setup for multiboxing in RIFT and not quite worth the effort... How long does it take you to hit Ctrl+C/Ctrl+V a few times? You will need a lot more macros for just the gameplay and these are highly specific to your spec and needs careful planning.

I use probably 40 macros on each character for various in-game abilities. I've actually run out of in-game space, so I've started re-using macros for many different souls. Like having a single macro for mouse-over insta-heal for all souls that have insta-heal capabilities. RIFT will skip over abilities that are invalid in a macro, so a single macro can work for many different specs.