Unholy would prioritize Unholy runes, the same as Frost prioritizes Howling Blast + Frost Strike.
Death Coil is likely your best runic power dump, with Rune Strike being your other option.
You would want to ensure your Unholy runes are constantly used if possible.
So you always have maximum benefit from Death's Advance.
Chance are, Blood runes would still be Blood Strike.
Your Frost runes would likely be Icy Touch for the application of Frost Fever.
Unholy is largely Diseases + Pet.
Not sure if you'd want Necrotic Strike or Plague Strike more.
Anti-healing vs greater raw damage.
Look at it from the point of view of amount of healing required to completely heal the target.
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