Free software...
Auto Hot Key
Hot Key Net
Mojo
Octopus

Paid software
IS Boxer
Game Commander Pro
Keyclone



HKN is probably the strongest of the free software options, especially if you like scripts and such. There are example scripts to start from.

IS Boxer, would be the best, in my opinion; but others will have other choices as to which is best.

Most of them are either free or have a trial version.