Thank you. I was trying it on a vista 64bit in the same manner as you have listed and the frame rate was worse than with just both monitors plugged into one card. It was acting like the old xp setups across multiple monitors. The 460 is a beast but it seems to have fps issues when i have wow across two monitors. The second i have isboxer put everything into monitor 1 all issues go away. I can still use internet browsers and anything else on the second monitor but when a wow window is on the second monitor is will eventually max out the gpu usage and then the usage will stay pegged until i exit out of wow and come back in. After that it will be fine for awhile but then the issue returns. All the time my gpu temp is at 42c. Very strange.

I have not tried it in win 7 but my guess is that would fix it.