An annoyance I've found with the <Run> command

[Freddie]

Every time I try this through HKN the running of the script fails with a "File cannot be loaded because the execution of scripts is disabled on this system" error.

That error message is coming from the operating system. HotkeyNet is simply relaying it to you.

If you post your hotkey definition here, maybe somebody can help you. There is no way for me to guess why you are having this problem because you didn't show the command that is causing the operating system to generate the error message.