Out of combat, everything (everything) works fine. Which is what I find most baffling.

What happens for the Shift Region:

OOC:
Casts all the spells, and works great.

IC:
Ignores the modifier, and either targets the player I tried to heal. Or opens the options menu.

One thing I did notice, is that it seems as if the priest is still trying to assist the main window.

I am using Clique with oUF Unit Frames. So not using either Healbot or Vuhdo (I don't like the aesthtics of either of them... I know, but I am picky!)