The free software options are HKN, AHK, and Octopus. The pay options are Keyclone, Game Commander Pro and IS Boxer. Of these, imo IS Boxer is the best and HKN is the next best; but an opinion is subjective. Most will give you a trial period to see if you like them for yourself.
IS Boxer has FTL assist, which means when you press '1', they will all auto assist the active character (can switch between characters freely) and also press '1'. No need for assist based macros of your own, just drag spells onto the hotbar.
Focus based assist is probably the easiest if you go with another software option. Basically, if you have five toons then you need five assist hotkeys. Each toon (on the same keybind) will have /Focus ToonA (using your first character's name here). If you switch to ToonC, you press the macro for ToonC to become everyone's focus. Then your spells are: /cast [Target=FocusTarget] Spell Name. Or /Follow [Target=Focus]
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