Hard to say what you might be missing without seeing your config. Instructions for sharing your config here: http://isboxer.com/forum/viewtopic.php?f=18&t=13

Randomly guessing:
1. If you didn't run the Quick Setup Wizard and select LOTRO in the top Game box, there's 2 options in your Character Set that should be checked for LOTRO. They both say LOTRO in parentheses, and one of them not being checked would 100% cause the described issue
2. If you created a new Key Map to make your new Mapped Keys (hotkeys), then it needs to be assigned to your Character Set, or at least the Character that you want to use it from. If you select one or the other in the top pane (the Key Map or the Character Set), then in the bottom left pane you will see the other listed. i.e. select your Key Map in the top pane and you should see your Character Set listed in the bottom left. If it's not there, drag from the top pane to the bottom left pane

If that doesn't help, you should definitely share your config