there are a few games that require active focus in order to process keyboard input... by default, the current release of keyclone does not support this (wait for the next release). currently, using Innerspace by lavishsoft to lock the lotro windows in the foreground is the solution

of course, if you have multiple machines, you can tied them all together with keyclone and run 1 copy of lotro on each (requires a keyclone per machine). that works currently.