Even with the removal of multiple castsequences called by click...
Even if the current castsequence + fall-through/proc is also removed...

We can go with matching cast time, on similar hotkeys.
And spam 1-4 keys for DPS, instead of 1 key.

Or we can go with straight castsequences.
And either have procs on another key, which we press every 5 or 10 seconds.
Or approximate the procs and include them in the castsequences.

DPS will work for mixed teams, however Blizzard leaves the macro system.
Mixed teams bring additional special moves to manage/hotkey.
Which can be more of a challenge in remembering which key to use when.
But is also more tools brought to bear on a given situation.