I run a mixed team of 80's.. Blood DK tank, Warlock and Resto Druid. I found it was easier and more effective now using ISBoxer to set-up the keys to send different presses to the team individually using steps. The problem is there is now very little of standard rotations left, therefore it is largely priorities.

In game I can't get a good Rune Strike macro to work effectively, however using ISBoxer I am able to click the Rune Strike key every second click of 1 button. Similiarly for Heart Strike and Death Strike it will basically fire which one is available (priority on Heart Strike) rather than using an in-game macro which hangs up the castsequence if awaiting runes.