<UseKeyAsModifier F12>
<Hotkey F12 LButton>
<SendLabel w3, w5>
<Clickmouse %TriggerMainKey%>
<RestoreMousePos>

Change F12 to whatever key you want to use.
Add or remove window names as appropriate.

I have my AOE on F11.

Hit F11, Hit F12, Click the mouse on the main screen. My Paladins {w1 and w4} drop Consecrate {thus no need for mouse passing to w1, w4}. Shaman and DK {w3, w5} drop Saronite Bomb and D&D.