A few thing I noticed...

My resolution got changed
All my macros got taken off my bars
The spell queuing system is hell annoying and makes it harder to react to procs
The blizzard raid frames is hell annoying and I can't seem to get rid of that tab on the left hand side
There is no icon for the social (friends, who, raid, chat) window on the bottom toolbar
Haven't mentioned it before but... forcing people to cookie cutter spec... gg blizz!

This is just from starting up the game