Yes, that key combination has worked the best for me as well.

I use "F" and then "U" for interacting with friendly, barter/vendor/quest NPCs. I also use this for looting dead mobs. I set up all of my toons with "Loot All" active. Then, I set the loot rule to Master Looter so I can assign special items as I please. This way, when my inventory is full, the /follow toons will automatically pick up the excess.

I use "DEL" and then "U" for object interaction (boss chests, quest harvest items, etc.). It also works great for resource nodes. As a three-boxer, I've set up some of my toons to run around with all three harvesters (ore, wood, scholar) active. That way, I just run up to any node, hit "DEL", then "U", and I can collect everything I come across.

The one thing I really wish existed (and I would absolutely love it if someone here could tell me of some legal way of doing so) is key mapping to target ONLY opposing players in PvMP. We've got keybindings to cycle through nearest players (which, if you're on creep side will get you creeps), cycle through enemies, which if creep side will get you not only Freep players but also any NPCs within range. I would love to have a way to essentially Tab-target only through opposing player characters.

I also seriously wish Turbine would fix the /follow AI code. It just plain sucks. I cannot recall the number of times I've lost toons because of the wide-arc antics of /follow. I tried just doing direct movement mapping once--once. All it took was the first stun/root on any one toon to realize that could never work. If all of your toons are not always right on top of each other, you have no choice bu to use /follow.

As an aside, I ran into my first six-boxer on Vilya. That was really nice to see.