In that case, we probably go with three or so DPS buttons.
One for effects which you only cast once, or maybe which are only worth casting on a boss. Maybe have an argument for [mod:alt] or [mod:ctrl] in there, so your Shammies can Flame Shock on this key, but your Warlock might or might not Curse of Elements on that press.
Then you have another key for the Castsequence - Looping Spam for each of your classes.
And another button for Proc type effects, which is then spammed every 'x' clicks instead of the default spam key.
Not sure if that is optimal, but it is the best solution I have so far, aside from using software to duplicate the effects of 'click and commas', which I'd prefer to avoid if Blizzard actually removes this feature from the game.
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