Quote Originally Posted by moosejaw View Post
The absolute easiest setup is "NUI" . It aligns itself to your screen resolution. No profiles necessary. The author stays on top of bug fixes and has beta and ptr versions up to date. NUI is hosted on wowinterface.

Notable features are automatic switching of unit frames when joining party/raids 10/25/40 mans. Integration of various optional addons such as Omen, recount, clique, fubar and titan panels.

Check it out, it is the lowest maintenance ui I have ever used. Saves boxers hours of ui setup and sh!t is always in the same spot for mouse repeating.
That addon looks like an absolute cluster f***.

I use this http://www.tukui.org/

or sometimes added layout packages based off of it that skin other addons to match it.
http://www.tukui.org/v2/forums/forum.php?id=4