I would probably look at a reasonable speed 5850 rather than 2x 250's for gfx, as it will be able to run 3 screens (using eyfinity) and give you better gaming performance than 2x 250's.
it will cost slightly more however, than the 250's.
As for screens the difference in price between a 20 & 22 is negligable, so i would make sure they are all the same size and probably go with something like:
3x IIyama Prolite E2271HDS 22" Widescreen LED Monitor - Black [PLE2271HDS]
if you got the eyfinity route, you will need to ensure that at least one of your monitors has a HDMI or display port connection, as one of the monitors will need to use this (the other two will use DVI)
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