Im using a Dell Studio XPS 16 (ATI 4870 1 GB) and a Macbook Pro (9600 M GT)

I have 1 external monitor in the middle (hooked up to the Dell) and one laptop on each side.

The dell runs my main and my healer at the same resolution (1680*1050) so I can do mouseover healing. The macbook pro runs the 3 dps at a lower res.

I use isboxer for multiboxing and Input Director for mouse control over the Macbook pro.

All I can say is that this works like a charm for 5 boxing, and I can take all my stuff on the road to