1 WoW folder + keyclone = 1 set of profiles, all your toons will have the same settings
1 WoW folder + keyclone + symlinks = 5 sets of profiles, you do what you want on each toon
Innerspace + ISBoxer = don't worry bout it.

***I think ***

do some more research and experiment with your 30 toons, there's no major right or wrong way (except rolling gnomes). For me half the fun was finding new stuff that you can do playing 5's.