What boxing software are you using? I'm using Innerspace and i have attack buttons setup so that IWT is called when key is pressed and actual attack when key is released. It works great!

Using IWT on main does work, but i would suggest NOT using it, because of couple of things:
#1 it makes guiding your toons around obsticals easier
#2 you rotate to look for a new target, but IWT forces you to face current target >.<
#3 gives you more freedom to stun targets, cast aoe etc.