Disclaimer: Not sure, we should use a Click like functionality, if Blizzard has chosen to remove it.
Not sure this would work, but theorizing...

Let's assume you have multiple abilities, each on their own cooldown.
And you want a priority system, the same as with Click.
For the example, let's say the old Balance Druid rotation.

You want:
A) Moonfire, every 15 seconds.
B) Insect Swarm, every 12 seconds.
C) Fall-Through of either Wrath or Starfire.

You'll have a spam key, which is mindlessly spammed over and over.
A consistent pace is less important, as the software is controlling when a step can advance instead of commas in a macro.

You will need something like MSBT or JambaProc to notify you when you gain a Lunar or Solar eclipse.
Have it tell you, to press the hot key for that druid's Toggle Key.

Spam Key
Do Mapped Key A
Do Mapped Key B
Do Mapped Key C
Do Mapped Key D

Mapped Key A
Step 1: Send Keybind for Moonfire to Warcraft.
Step 2: Do Not Advance for 15 Seconds.

Mapped Key B
Step 1: Send Keybind for InsectSwarm to Warcraft
Step 2: Do Not Advance for 12 Seconds.

Mapped Key C
Step 1: Send Keybind for Wrath to Warcraft

Mapped Key D
Step 1: Send Keybind for Starfire to Warcraft

Toggle Key
Step 1: Enable Mapped Key C; Disable Mapped Key D
Step 2: Disable Mapped Key C; Enable Mapped Key D