FTL (focusless targetless leadersless setup) is only really any useful for serious pvp.
Any of the Focus, Target, or Leader setups work fine the rest of the time, especially focus and target based ones.
But indeed, especially for lower number of characters, FTL is even more pointless.

With focus (maybe target or leader too) setup, you can set your ability macros up with conditionals so that they work correctly regardless of who is the master (the character knows through the macro whether or not the are the leader).

Examples of this can be seen in the (now slightly old) thread about my setup, linked in my signature, since I do this for most of my macros.