If you're having a long conversation you're not progressing through the instance anyway, regardless of single boxing or multiboxing. It seems really extreme to me to make all your spells shift/ctrl/alt modified just so you can use your regular keys for chatting, when it's very simple to just hit one key to turn everything on or turn everything off. I personally use shift/ctrl/alt modifiers to cast different spells - plus I can use capital letters while chatting without casting some random spell.
But, if it works for you then great! I just wouldn't recommend that playstyle to anyone.
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