I've had it since it first came out. I originally bought it to play Aion, but I don't play that game anymore. When I first got it, I worried about how fragile the keys looked and felt. After almost a year, I Absolutely love the Naga. I wouldn't go back to using another mouse for gaming. For me it made PvP a ton easier. However, It wasn't the easiest mouse to get used to.

It took me about a month (with training tabs on) to get used to it. My forearm would be so tired after using it for extended game play. But now my thumb just instictively knows where to go, and my forearm doesn't hurt anymore. I don't get lost much because of the raised tabs on the keys. I've been wanting to try completely driving with it... i.e. w,a,s,d, strafe, camera, turns... etc., but I've yet to muster the stones to go through the re-training.

I trained by setting up the "Naga Bars" exactly like my N52 and naga keys. Each keypress had a visual representation on my UI. I made the bars small so they don't take up much space, but large enough to where I can still see them. Then I would place a spell or macro icon on the bar that coincides with the buttons on the Naga and N52. I was able to figure out what types of spells worked well on the mouse this way.

I use the naga to drop totems, call out my pets, drain life, drain soul, blink, purge... etc (multiple toons, multiple classes...obviously). I do agree that M4 and M5 are in a bad location ( I think E.T. was the beta tester). So I just use them mainly for Auto-Run and Shapeshifting on my druid. The mouse wheel is a bit clicky too, I only use it to scroll through my buffs.

I think completely committing to it is the key to making this mouse work for you. I gave away my other mice to family and friends. So it was make it work or buy a new mouse.