Keyclone's mouse broadcasting never worked terribly well for me. It was ok for dropping the occasional targetted AOE spell, but it never seemed to be accurate or reliable enough for healing. I had to stick with individual macros to heal like TheFunk mentions.

Most people seem to use Innerspace with Vuhdo or some other mod, but there's more than a few guides for setting that up and how it works, so I've got nothing to offer on that. I've only used Innerspace/ISBoxer in EQ2 and only for a few months.

I use HotKeyNet. However, you'll need to understand the language to write the scripts. A couple examples here and here. You can also configure the hotkeys themselves to simply be reactive based on position without actually passing the mouse, which gives you the reliability of per-toon macros with the ease of mouseover.