My very first multibox team is a 5-man Pally/Lock/Shaman/Mage/Priest setup and it's going pretty well. So far I've been able to tackle every instance including daily heroics, albeit some encounters usually involve 5-10 wipes before I figure it out. It did take a little while setting up macros and I'm constantly tweaking them, but despite the class diversity I only have to hit between 1-3 keys during combat and I still have access to many of the class specific special abilities (Hex, Purge, Counterspell, Poly, Mirror Image, etc...). For those I use repeater regions with bartender action bars.
VuhDo + ISBoxer repeater regions I use for the group healing, with 3 physical hotkeys also setup for tank healing (FoL, Penance, and a "panic" heal button that has my shaman stop his DPS and cast quick heals on the tank while the priest does a big one). Most healing is pretty easy, from my main screen (the Paladin) I right click on the name to have the priest cast PW:S, left click for FoL, Shift-left for greater heal, etc...
Stick with the regular keyboard for now, but if you were to upgrade I'd seriously look at a G13 rather than a G15. It takes a little bit of getting used to, but now I can't imagine doing it any other way. You have more buttons at your disposal including an analog thumb-stick which is perfect for controlling slave movement.
I make wide use of the alternate profiles with the G13. With a quick button press I switch my team from normal DPS rotations to burst DPS for movement heavy fights, or "special" DPS for fights that involve mounted combat or some other oddity. The pad offers color coding for whatever setup you choose, so it's easy to see which setup is active and on the fly switching is instant and painless.
I also have a NAGA MMO mouse, but I've only recently started to make use of its 12 available keys, as the G13 has provided more than enough button real-estate. It's looking more like the mouse buttons will be used for when I'm running solo with one of my team and need quick access to the abilities I typically ignore when running as a group.
This was my goal too and it has been a blast. I've been 5-boxing for about two months or so now, got my team to 80 a couple weeks back and so far haven't hit a heroic daily that I haven't been able to tackle with a little bit of work. I don't go as fast as pugs, but I'm typically finishing a dungeon in 20-40 minutes. I imagine as my GS gets higher that will speed up (sitting at around 3200-3500 on each toon atm). You're gonna love tackling the dungeons by yourself, overcoming difficult fights through trial and error and learning each of the different phases and abilities a boss has.
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