Try choosing safe mode. If it runs ok in safe mode, then you may have some sort of driver conflict (which would be weird if this is a new install). If it was a new install, did you get any errors while installing windows?

If the drive was from another system and already has windows on it, then it very well may be a driver problem. Go into safe mode and unistall chipset drivers and see if that helps. Then install the drivers that came with the new motherboard.