I'm currently boxing 3 locks. I'm using a N52 and a Naga mouse along with ISBoxer and Jamba. I have the Ctrl+(1,2,3 ..etc) keys tied to the pet bar. Ctrl +1 is petattack. I also have /petattack as the first line in my dps macro. I have my pet's on defensive as mentioned above. When I need to tank a mob before I dot, I just "target/ ctrl+1" and all three pets take off after the mob.

Be careful tab targeting because you might not like the outcome. What's nearest to your main may not be what's closest to your slaves... then it's voidwalkers gone wild. If I see them taking off for some other mob I just ctrl+2 and bring 'em back. Sometimes it's too late, so I'll sac them and wait for the pain.

Up to this point I haven't had to write many macros. Just the standards mainly, but then again, I'm boxing same class / same race. As far as ISBoxer reducing macros... think about having to write all the FTL macros yourself.... mistake free. That's a ton of macros you don't have to write because ISBoxer does that for you. You're always going to need some macros, but right now I'm using only 2 with my locks @ 58. One is my "big button" macro, the other is my dps macro. The rest are keybinds, and a few custom FTL keys for round robin fears and formations. When they start raiding and doing heroics, I'll switch to Fur's destruction lock click macro set up found in the Wiki.