I'm a bit biased, but I love this method compared to other software I've used in the past. I use this with my mixed team (paladin, priest, mage, shaman, warlock). Here's how I have each configured.

Code:
        | Region1 (nomod)   | Region2 (Shift)   | Region3 (Ctrl)
--------+-------------------+-------------------+-------------------------
Left    | Flash Heal        | Renew             | Greater Heal
--------+-------------------+-------------------+-------------------------
Middle  | Prayer of Mending | Binding Heal      | Power Word: Shield
--------+-------------------+-------------------+-------------------------
Right   | Circle of Healing | Prayer of Healing | Abolish Disease
        |                   |                   | Remove Curse
        |                   |                   | Cure Toxins
--------+-------------------+-------------------+-------------------------
Button4 | Guardian Spirit   |                   | Dispel Magic
--------+-------------------+-------------------+-------------------------
Button5 | Water Walking     | Fear Ward         | Detect Invisibility
        | Unending Breath   |                   |
--------+-------------------+-------------------+-------------------------