This sounds like target switching lag that we all experience as multiboxers. You've never been able to instantly switch targets and begin DPSing immediately. This is a limitation in World of Warcraft due to your latency to the server, not an issue with any software.
When you press a number key it does FTL Assist Me by default. FTL Assist Me happens to use the Backspace key, again by default. Either type the numbers out [one, two, three, etc], change the FTL Assist Me key combination, use the number pad, or remove auto assist from your FTL DPS keys in ISBoxer and use a manual assist.
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