I played on the Landroval server, 50 burglar, 50 champion, and was in the process of leveling a guardian and mistrel together. Auto-Follow breaks on every little thing, target forwarding is somewhat useful, but did not really work well for conjunctions/healing. About the best solution I came up with was programming my X-Keys with keystrokes for hotkeyable commands. For instance, binding the conjunction assist to the tilde key and then having that programmed on my X-Keys followed by hotkeying the red/blue/yellow/green commands to keys. I healed via programming X-Keys as such: (F1)(9) on the same key with 9 being my fast heal. This would target me then cast my fast heal with one keypress on the X-Keys. I did the same for the other party members and also duplicated this using 0 for my big heal.

I never found a good way to macro anything other than some very basic emotes and ;loc command. Assist was what I was really hoping to get working. Right before I found dual-boxing.com, I was looking for some help to get a guardian/minstrel two box going. That is how I found dual-boxing.com (through a google search). LotRO just doesn't seem to have an interface or macro system that is usuable, much less multi-box friendly.