Well the only other problem I think I would have found is the actual clicking now.

IE: If on my tank, and using Shift + Click to heal, what is the best way to have my tank keep the target? Create a macro for Clique to /targetnearestenemy or what?

I did a /targetlasttarget and it was a bit annoying because if I am spamming heals, it wouldn't update targets fast enough and sometimes cause me to target a dead mob.