After I close the messed up window things relaunch with no problem. When I set up my screen regions I just used the Wizard. My Windows Vista is the 32bit version btw.
So we have 3 different OS' experiencing the same problem which makes me think it might be a bug in ISboxer itself. What you guys are saying sounds identical to what happens to me.
At least it doesn't happen THAT often- but it sure can happen at the worst times- lol. Seems to come and go really. That one day it was happening over and over for some reason.
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