The above poster was correct -- you need to run MacroWorks 3 as an administrator to pass keystrokes onto some software on Vista or 7.

Additionally, if you happen to be on a Mac, OS X doesn't allow modifiers to be combined with another keyboard's keys. So you could do Ctrl on the X-keys and you could do 7 on your normal keyboard, but you couldn't combine them for Ctrl+7. This is only the case with OS X, not Windows, and affects all keyboards.

Please feel free to contact me personally. I work for P.I. Engineering (we make the X-keys) in tech support and I'd be glad to help you troubleshoot. E-mail is amberm@piengineering.com and phone number is 517-655-5523 extension 19.